Neomycin

Overview

Neomycin is an aminoglycoside antibiotic used orally to reduce gut bacterial load. In the context of cholangiocarcinoma (CHOL), oral neomycin has been evaluated as a microbiota-modulating adjuvant, with proposed benefit through blocking the CXCL1–PMN-MDSC axis driven by TLR4 signaling.

Evidence in the corpus

• Oral neomycin blocks the TLR4-driven CXCL1–PMN-MDSC axis in CCA preclinical models, reducing immunosuppressive myeloid-derived suppressor cell recruitment to the tumor microenvironment PMID:25608663

Resistance mechanisms

Cancer types (linked)

• CHOL — cholangiocarcinoma

Sources

• PMID:25608663

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