CXCL1

Overview

CXCL1 (C-X-C Motif Chemokine Ligand 1) is a pro-inflammatory chemokine secreted by hepatocytes downstream of TLR4 signaling. In cholangiocarcinoma, CXCL1 recruits polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) to accelerate tumor progression; this axis can be disrupted by neomycin.

Alterations observed in the corpus

• TLR4-driven hepatocyte chemokine that recruits PMN-MDSCs to accelerate cholangiocarcinoma progression; neomycin blocks the CXCL1-PMN-MDSC axis in preclinical models PMID:25608663

Cancer types (linked)

• Cholangiocarcinoma: CXCL1-mediated PMN-MDSC recruitment promotes tumor progression PMID:25608663

Co-occurrence and mutual exclusivity

Therapeutic relevance

• Neomycin blocks the CXCL1-PMN-MDSC recruitment axis in preclinical cholangiocarcinoma models PMID:25608663

Open questions

Sources

• PMID:25608663

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