ABCB11
Overview
ABCB11 (ATP-binding cassette sub-family B member 11, also known as BSEP) encodes the bile salt export pump expressed in hepatocytes. In cancer genomics, ABCB11 is notable as a fusion partner in HCC: the ABCB11–LRP2 fusion is the first recurrent gene fusion reported in hepatocellular carcinoma, identified by integrated genomic analysis circa 2014.
Alterations observed in the corpus
- Recurrent gene fusion ABCB11–LRP2 reported as the first recurrent fusion in HCC, identified by next-generation sequencing; represents a novel structural alteration class in HCC beyond point mutations PMID:24735922
- Identified as a prognostic marker of the bile-acid-active CCA subtype (bile-salt export pump); implicated in bile acid homeostasis maintenance in cholangiocarcinoma PMID:25608663
Cancer types (linked)
- HCC: involved as fusion partner (ABCB11–LRP2) in HCC; clinical significance of the fusion beyond its novelty as a structural event is not yet established PMID:24735922
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data available in this corpus.
Therapeutic relevance
- No direct therapeutic relevance reported in this corpus.
Open questions
- Functional consequence and prevalence of the ABCB11–LRP2 fusion across broader HCC cohorts is not yet established PMID:24735922.
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:25608663
This page was processed by crosslinker on 2026-05-14.