AXIN2

Overview

AXIN2 (Axis Inhibition Protein 2; also Conductin) is a scaffold protein in the beta-catenin destruction complex and a negative regulator of WNT/beta-catenin signaling. Together with AXIN1 and APC, recurrent mutations in AXIN2 define a WNT-pathway alteration cluster in pancreatic ductal adenocarcinoma, nominating tankyrase inhibitors as potential therapeutic candidates.

Alterations observed in the corpus

  • Recurrently mutated WNT-pathway component in pancreatic ductal adenocarcinoma (PDA); co-mutated with AXIN1 and APC, nominating tankyrase inhibitors (XAV939) as therapeutic candidates PMID:25855536

Cancer types (linked)

  • PAAD — recurrent somatic mutations; part of a broader WNT-pathway alteration cluster PMID:25855536

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • AXIN2 mutations, together with AXIN1 and APC alterations, nominate tankyrase inhibitors such as XAV939 in PDA PMID:25855536

Open questions

  • Frequency of AXIN2 mutations in PDA and their specific functional consequences vs. AXIN1 require further study.

Sources

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