BRPF1

Overview

BRPF1 (Bromodomain and PHD Finger-Containing Protein 1) is a scaffold subunit of the MOZ/MORF histone acetyltransferase (HAT) complex, which mediates H3K14 acetylation and controls transcriptional activation. In cancer, BRPF1 alterations are implicated in disruption of HAT-complex activity, particularly in pediatric brain tumors.

Alterations observed in the corpus

  • BRPF1 is among the recurrent HAT-complex gene alterations found in 19% of SHH medulloblastomas alongside CREBBP, KAT6B, EP300, and KANSL1; HAT-complex alterations are predominantly restricted to the SHH subgroup PMID:28726821.

Cancer types (linked)

  • Medulloblastoma (SHH subgroup): BRPF1 alterations occur as part of a broader HAT-complex disruption affecting 19% of SHH MBs, suggesting HAT-pathway-targeted epigenetic therapy as an avenue meriting further study PMID:28726821.

Co-occurrence and mutual exclusivity

  • BRPF1 alterations co-occur with other HAT-complex genes (CREBBP, KAT6B, EP300, KANSL1) predominantly in SHH medulloblastoma PMID:28726821.

Therapeutic relevance

  • The 19% HAT-complex alteration rate in SHH MBs, including BRPF1, suggests HAT-pathway-targeted epigenetic therapy as an avenue meriting further preclinical and clinical study PMID:28726821.

Open questions

  • The specific functional consequence of individual BRPF1 mutations within the HAT complex in SHH MB and their differential drug sensitivity remain to be characterized.

Sources

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