KAT6B

Overview

KAT6B (Lysine Acetyltransferase 6B) encodes a MYST-family histone acetyltransferase that acetylates histone H3 at lysine 9 and lysine 14. It forms part of the MOZ/MORF HAT complex and plays roles in developmental gene regulation. In cancer genomics, KAT6B is a recurrently mutated HAT-complex subunit in medulloblastoma.

Alterations observed in the corpus

Cancer types (linked)

  • SHH medulloblastoma: HAT-complex subunit altered as part of a recurrent epigenetic driver class affecting 19% of SHH tumors PMID:28726821

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • HAT-complex alterations in SHH medulloblastoma may sensitize to epigenetic therapeutic approaches, though no direct targeted therapy is established.

Open questions

  • The relative contribution of KAT6B vs. other HAT-complex members to medulloblastoma pathogenesis remains unclear.

Sources

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