BUB1
Overview
BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) encodes a kinase essential for the spindle assembly checkpoint (SAC), ensuring accurate chromosome segregation during mitosis. BUB1 phosphorylates histone H2A at threonine 120, a mark required for proper centromeric cohesion. Aberrant BUB1 expression contributes to chromosomal instability in cancer.
Alterations observed in the corpus
- Upregulated in the basal-like IntClust 10 subgroup as part of a chromosome 5q deletion-associated trans-acting mitotic network in the METABRIC breast cancer cohort (2,000 tumors) PMID:22522925
- No genomic alterations observed in this bladder TCC cohort (99 tumors) despite BUB1 being reported altered in other cancer types; BUB3, MAD1L1, MAD2L1, and CENPE were similarly unaltered PMID:24121792
Cancer types (linked)
- BRCA (breast cancer): Transcriptional upregulation in basal-like IntClust 10, a subgroup associated with high chromosomal instability and poor prognosis PMID:22522925
Co-occurrence and mutual exclusivity
- Co-upregulated with AURKB, CHEK1, FOXM1, and TTK in the basal-like IntClust 10 subgroup, collectively forming a mitotic dysregulation network driven by cis-acting 5q deletions PMID:22522925
Therapeutic relevance
- No approved agents directly targeting BUB1; upregulation in basal-like breast cancer suggests potential as a therapeutic vulnerability in combination with mitotic checkpoint abrogators.
Open questions
- The functional consequence of BUB1 overexpression in IntClust 10 (driver vs. passenger) requires experimental dissection.
Sources
This page was processed by entity-page-writer on 2026-05-06. - PMID:24121792
This page was processed by wiki-cli on 2026-05-09.