CACNA1D

Overview

CACNA1D encodes the alpha-1D subunit of a voltage-dependent L-type calcium channel (Cav1.3). In cancer genomics, CACNA1D has been observed as a somatically mutated gene in gastric cancer, with the p.V529G missense variant notable for being shared between two patients in a multi-region sequencing study, suggesting either a convergent selective pressure or a shared mutational mechanism.

Alterations observed in the corpus

  • Missense p.V529G variant shared between two distinct gastric cancer patients (Pt1 and Pt2) in a multi-region WGS clonal evolution study of 294-patient Tianjin WES cohort PMID:25583476

Cancer types (linked)

  • Gastric cancer (STAD): The p.V529G variant observed in two independent patients in a clonal architecture study; its recurrence across patients suggests potential selective advantage PMID:25583476

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic targeting of CACNA1D reported in the corpus; the shared mutation across patients may merit investigation as a candidate driver.

Open questions

  • Whether p.V529G is functionally activating or loss-of-function in the gastric cancer context is unknown.
  • The mechanism by which independent gastric cancer patients share this exact variant is not explained in the source paper.
  • Broader prevalence in population-scale gastric cancer datasets is not reported in the corpus.

Sources

This page was processed by crosslinker on 2026-05-14.