CD5
Overview
CD5 is a cell surface glycoprotein expressed on T cells and a subset of B cells. In chronic lymphocytic leukemia (CLL), CD5 expression is a defining diagnostic marker of the malignant B-cell clone. Its upregulation in SF3B1-mutant CLL cells provides functional context for understanding the transcriptional consequences of SF3B1 co-mutation with del(13q).
Alterations observed in the corpus
- CD5 mRNA and protein upregulated in SF3B1-mutant / del(13q) double-mutant (DM) CLL cells compared to single-mutant or wild-type controls; serves as a CLL marker gene confirming the disease phenotype of DM CLL cells in the murine model PMID:26200345
Cancer types (linked)
- CLLSLL: upregulated in DM CLL murine model (SF3B1-K700E + del(13q) Mdr); co-upregulated with ZAP70 as CLL-defining surface markers PMID:26200345
Co-occurrence and mutual exclusivity
- Co-upregulated with ZAP70 in SF3B1-K700E / del(13q) double-mutant CLL cells PMID:26200345
Therapeutic relevance
- No direct therapeutic associations identified in this corpus; CD5 upregulation confirms CLL identity in the DM model rather than representing a therapeutic target.
Open questions
- Whether CD5 expression level correlates specifically with SF3B1 mutation status in human CLL patients is not directly tested in this study PMID:26200345
Sources
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