CRLF2
Overview
CRLF2 (Cytokine Receptor Like Factor 2) encodes a type I cytokine receptor that heterodimerizes with IL7R to form the thymic stromal lymphopoietin (TSLP) receptor complex. CRLF2 is a recurrently altered gene in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), where rearrangements, splice-site mutations, and overexpression contribute to JAK-STAT pathway activation and leukemogenesis.
Alterations observed in the corpus
- CRLF2 splice alterations are listed as a capture-kit-excluded event of biological interest in the TCGA MC3 MAF resource: the Broad BED mask (bitgt filter) removes CRLF2 splice-site variants because they fall outside the capture footprint, representing a known systematic gap in the pan-cancer somatic variant call set PMID:29596782.
Cancer types (linked)
- Predominantly altered in BCP-ALL; also observed in Down syndrome-associated ALL.
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
Sources
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