CTTN

Overview

CTTN (Cortactin) is an actin-binding protein encoded on chromosome 11q13 that promotes actin polymerization and is involved in cell motility and invasion. In HNSCC it is co-amplified with CCND1 and FADD as part of a recurrent 11q13 amplification cassette.

Alterations observed in the corpus

  • 11q13 co-amplification cassette with CCND1 and FADD in 31% of HPV(-) HNSCC vs. 3% of HPV(+) tumors (279-tumor TCGA cohort) PMID:25631445

Cancer types (linked)

  • Head and neck squamous cell carcinoma (HNSC): 11q13 co-amplification enriched in HPV(-) subtype PMID:25631445

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

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