FADD
Overview
FADD (Fas-Associated Death Domain) encodes an adaptor protein central to extrinsic apoptosis signaling downstream of death receptors. In cancer genomics, FADD is notable as a component of the 11q13 amplicon in oral squamous cell carcinoma (OSCC), a region containing the cyclin D1 (CCND1) locus, where co-amplification of FADD and related apoptosis modulators may contribute to oncogenic phenotypes.
Alterations observed in the corpus
- Located within or near the 11q13 CCND1 amplicon with strong copy-number-to-expression correlation in OSCC; possibly contributes alongside CCND1, BIRC2, BIRC3, and IKBKB to the oncogenic effect of this amplicon PMID:23619168
- Part of 11q13 co-amplification cassette (31% in HPV(-), 3% in HPV(+) HNSCC) together with CCND1 and CTTN; BIRC2 interaction with FADD-caspase cascade inferred to inhibit cell death PMID:25631445
Cancer types (linked)
- OSCC: Focal high-level amplification at 11q13 in oral squamous cell carcinoma as part of the CCND1 amplicon PMID:23619168
Co-occurrence and mutual exclusivity
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus; co-amplification context within the 11q13 amplicon may be relevant to apoptosis resistance in OSCC.
Open questions
- Whether FADD amplification independently contributes to OSCC oncogenesis beyond co-amplification with CCND1 has not been established.
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:25631445
This page was processed by crosslinker on 2026-05-14.