CXCL10

Overview

CXCL10 is an IFN-gamma-inducible CXCR3 ligand that recruits effector T and NK cells to tumor sites.

Alterations observed in the corpus

• Included in the 20-gene Immunologic Constant of Rejection (ICR) signature as a CXCR3/CCR5 chemokine ligand, alongside CCL5 and CXCL9, in the 348-patient AC-ICAM colon cancer cohort PMID:37202560.

Cancer types (linked)

• Colon adenocarcinoma — CXCL10 contributes to ICR-based stratification that is prognostic for overall survival PMID:37202560.

Co-occurrence and mutual exclusivity

• Co-expressed with the other ICR Th1/chemokine and effector module genes in ICR-high colon tumors PMID:37202560.

Therapeutic relevance

• No direct CXCL10-targeting therapy is evaluated; it contributes to the prognostic ICR module PMID:37202560.

Open questions

• Independent contribution of CXCL10 vs the ICR module is not dissected PMID:37202560.

Sources

• PMID:37202560

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