DLEU1

Overview

DLEU1 (Deleted in Lymphocytic Leukemia 1) is a long non-coding RNA gene residing within the minimal deleted region (Mdr) of chromosome 13q14, a region recurrently deleted in chronic lymphocytic leukemia (CLL). DLEU1 loss cooperates with other genomic alterations to drive CLL pathogenesis.

Alterations observed in the corpus

Comprises the minimal deleted region (Mdr) of 13q14 along with DLEU2 and MIR15A; modeled as a floxed deletion in murine CLL models; Mdr loss alone gives low-penetrance CLL but cooperates with SF3B1 mutation for full disease acceleration PMID:26200345

Cancer types (linked)

CLLSLL: Part of the recurrent 13q14 minimal deleted region; cooperates with SF3B1 K700E mutation to accelerate CLL development in murine models PMID:26200345

Co-occurrence and mutual exclusivity

Co-deletion with DLEU2 and MIR15A at 13q14; double-mutant (SF3B1-K700E + del(13q)) CLL shows inferior OS vs single-lesion CLL PMID:26200345

Therapeutic relevance

Open questions

Sources

PMID:26200345

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