DLEU2

Overview

DLEU2 (Deleted in Lymphocytic Leukemia 2) is a long non-coding RNA gene at chromosome 13q14, co-deleted with DLEU1 and MIR15A in the minimal deleted region (Mdr) recurrently lost in chronic lymphocytic leukemia (CLL). Its loss cooperates with oncogenic SF3B1 mutations to accelerate CLL.

Alterations observed in the corpus

Comprises the minimal deleted region (Mdr) of 13q14 along with DLEU1 and MIR15A; Mdr loss alone gives low-penetrance CLL but cooperates with SF3B1 K700E mutation for full disease acceleration in murine models PMID:26200345

Cancer types (linked)

CLLSLL: Part of the recurrent 13q14 minimal deleted region; co-deletion with DLEU1/MIR15A plus SF3B1 K700E mutation defines an aggressive CLL subtype with inferior OS PMID:26200345

Co-occurrence and mutual exclusivity

Co-deleted with DLEU1 and MIR15A at 13q14; double-mutant SF3B1-K700E + del(13q) CLL shows shorter time to first therapy and inferior OS compared to single-lesion CLL PMID:26200345

Therapeutic relevance

Open questions

Sources

PMID:26200345

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