DNMT3B

Overview

DNMT3B encodes DNA methyltransferase 3 beta, a de novo DNA methyltransferase responsible for establishing methylation patterns during embryonic development and in adult tissues. In cancer, DNMT3B dysregulation contributes to aberrant CpG island methylation, silencing of tumor suppressor genes, and genomic instability. Somatic mutations in DNMT3B have been identified in colorectal and other cancers, and the gene has emerged as a univariate survival correlate in metastatic colorectal cancer.

Alterations observed in the corpus

  • Univariate survival-associated alteration in MSS metastatic colorectal cancer identified by MSK-IMPACT sequencing of 1,134 colorectal adenocarcinomas; DNMT3B did not retain significance in the multivariate model (which retained APC, BRAF, KRAS, and NRAS) PMID:29316426

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • No co-occurrence or mutual exclusivity data in the current corpus.

Therapeutic relevance

  • No direct therapeutic targeting data in the current corpus.

Open questions

  • DNMT3B did not hold up in multivariate survival analysis in the Yaeger et al. mCRC cohort; the biological mechanism linking DNMT3B mutation to prognosis remains to be established PMID:29316426

Sources

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