EBF1
Overview
EBF1 (Early B-Cell Factor 1) is a transcription factor essential for B-cell development and differentiation. In diffuse large B-cell lymphoma (DLBCL), EBF1 is selectively essential in the activated B-cell-like (ABC) subtype, where it plays a role in NF-κB signaling and B-cell identity maintenance. Its ABC-selective CRISPR essentiality supports it as a subtype-specific dependency.
Alterations observed in the corpus
- EBF1 demonstrates ABC-selective CRISPR essentiality in DLBCL, implicating it in B-cell-development and NF-κB signaling dependencies specific to the ABC subtype PMID:28985567.
Cancer types (linked)
- DLBCLNOS (Diffuse Large B-Cell Lymphoma): EBF1 is an ABC-DLBCL-selective CRISPR essential gene, functionally linked to NF-κB pathway survival signaling alongside CARD11, MYD88, and IKBKB PMID:28985567.
Co-occurrence and mutual exclusivity
- EBF1 ABC-selective essentiality co-clusters with IKBKB, CARD11, MYD88, and IRF4 as ABC-selective CRISPR dependencies in DLBCL PMID:28985567.
Therapeutic relevance
- ABC-selective CRISPR dependencies including EBF1 reinforce NF-κB pathway targeting (e.g., BTK inhibitors, IRAK inhibitors) for ABC-DLBCL patients PMID:28985567.
Open questions
- The specific mechanism by which EBF1 maintains NF-κB signaling in ABC-DLBCL (versus its canonical role in B-cell development) is not established.
Sources
This page was processed by crosslinker on 2026-05-15.