IRF4
Overview
IRF4 (Interferon Regulatory Factor 4) is a transcription factor critical for lymphocyte differentiation and plasma-cell survival. IRF4 is a known multiple myeloma survival factor, and recurrent hotspot mutations have been identified in MM genomic studies.
Alterations observed in the corpus
- IRF4 harbors recurrent K123R hotspot mutation in 3 of 4 IRF4-mutant multiple myeloma patients; IRF4 is a known MM survival factor PMID:24434212
- Oncogenic missense mutations; CRISPR-essential selectively in ABC DLBCL; used in Hans IHC algorithm for cell-of-origin classification; reinforces NF-κB pathway targeting for ABC DLBCL. PMID:28985567
Cancer types (linked)
- MM: recurrent K123R hotspot mutation; IRF4 is an established MM survival factor PMID:24434212
Co-occurrence and mutual exclusivity
- IRF4 K123R hotspot observed in the context of a broader somatic-hypermutation landscape including CCND1, EGR1, and other MM drivers PMID:24434212
Therapeutic relevance
- IRF4 is a known dependency in multiple myeloma; hotspot K123R mutations may affect transcriptional activity relevant to MM cell survival PMID:24434212
Open questions
- Functional consequence of IRF4 K123R on transcriptional activity and MM cell survival not characterized in this study PMID:24434212
Sources
This page was processed by crosslinker on 2026-05-09. - PMID:28985567
This page was processed by entity-page-writer on 2026-05-15.