EPHA6
Overview
EPHA6 (Ephrin Type-A Receptor 6) is a receptor tyrosine kinase of the EPH family. It has been proposed as an African American-specific colorectal cancer driver gene, with somatic mutations enriched in AA CRCs compared to Caucasian CRCs, and a mutation pattern consistent with tumor-suppressor activity.
Alterations observed in the corpus
- 6 somatic mutations in AA CRCs (one splice-site plus four missense predicted to significantly alter function); mutated in 5.83% AA vs. 0% Caucasian CRCs (P=0.007); pattern consistent with tumor-suppressor activity; proposed as an AA-specific CRC driver PMID:25583493
Cancer types (linked)
- CRC: Enriched in African American colorectal cancers; mutated in 5.83% AA vs. 0% Caucasian; ethnicity-associated EPH family selection PMID:25583493
Co-occurrence and mutual exclusivity
- Related EPH family members EPHA3 and EPHB6 were identified as significantly mutated in a prior nearly all-Caucasian MSS CRC cohort, suggesting ethnicity-associated selection of different EPH family members PMID:25583493
Therapeutic relevance
- Drugs (linked) targeting this gene or its pathway, with the studies supporting them.
Open questions
- Functional consequences of EPHA6 mutations in AA CRCs were not experimentally tested PMID:25583493
Sources
This page was processed by crosslinker on 2026-05-14.