EPHB6

Overview

EPHB6 (Ephrin Type-B Receptor 6) is a member of the EPH receptor tyrosine kinase family. It has been identified as a significantly mutated gene in Caucasian microsatellite-stable (MSS) colorectal cancers, representing an example of how different EPH family members are selected in different ethnic backgrounds in CRC.

Alterations observed in the corpus

• Identified as a significantly mutated gene in a prior nearly all-Caucasian MSS CRC cohort; cited alongside EPHA3 as evidence of ethnicity-associated selection among EPH family members PMID:25583493

Cancer types (linked)

• Per cancer type: prevalence, co-mutation patterns, clinical significance.

Co-occurrence and mutual exclusivity

• EPHA6 is selected in African American CRCs whereas EPHA3 and EPHB6 are selected in Caucasian CRCs, suggesting ethnicity-associated selection of different EPH family members PMID:25583493

Therapeutic relevance

• Drugs (linked) targeting this gene or its pathway, with the studies supporting them.

Open questions

• Conflicts or unresolved findings across papers.

Sources

• PMID:25583493

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