ETV5

Overview

ETV5 is an ETS family transcription factor and a known transcriptional target of CIC (capicua transcriptional repressor). In oligodendroglioma, where CIC loss-of-function mutations are recurrent, ETV5 derepression serves as a functional readout of CIC inactivation.

Alterations observed in the corpus

• ETV5 expression is upregulated in cells carrying a subclonal CIC loss-of-function mutation (~30% VAF) in the MGH53 oligodendroglioma; the increased ETV5 (and ETV1) expression in CIC-mutant cells is consistent with derepression of known CIC target genes, and this mutation spans all three developmental compartments (stem/progenitor, oligodendrocyte-like, astrocyte-like) PMID:27806376.
• ETV5 identified as an ETS family fusion gene in prostate cancer WES cohort (Michigan, 112 tumors); rearrangements contribute to ETS-driven transcriptional dysregulation PMID:22722839
• Recurrent ETS fusion in mCRPC (part of 56% ETS-fusion prevalence) PMID:26000489

Cancer types (linked)

• ODG — ETV5 derepression in CIC-mutant oligodendroglioma cells; subclonal mutation present across all tumor compartments, suggesting CIC mutation is an early event PMID:27806376.

Co-occurrence and mutual exclusivity

• ETV5 derepression co-occurs with ETV1 derepression in CIC-mutant oligodendroglioma cells PMID:27806376.

Therapeutic relevance

• Not directly targeted in the corpus; ETV5 upregulation is a functional biomarker of CIC inactivation PMID:27806376.

Open questions

• Whether ETV5 derepression contributes to the developmental plasticity of oligodendroglioma or is merely a passenger consequence of CIC loss is unresolved PMID:27806376.

Sources

• PMID:27806376

• PMID:22722839

• PMID:26000489

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