FAT2

Overview

FAT2 is a member of the FAT cadherin family of tumor suppressor genes. In esophageal squamous cell carcinoma (ESCC), FAT2 harbors recurrent truncating mutations that are mutually exclusive with FAT1 and FAT3 mutations, and shRNA-mediated knockdown promotes xenograft tumor growth, supporting a functional tumor suppressor role.

Alterations observed in the corpus

  • Recurrent truncating mutations in ESCC (139 paired tumor/germline samples by whole-exome/targeted sequencing); shRNA knockdown promotes xenograft growth; mutations mutually exclusive with FAT1 and FAT3 PMID:24686850
  • Recurrent HBV integration site near FAT2 oncogene in intrahepatic cholangiocarcinoma (iCCA); HBV insertional mutagenesis may drive expression. PMID:25526346

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

  • The downstream mechanisms of FAT2 tumor suppression in squamous epithelium are incompletely characterized.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:25526346

This page was processed by crosslinker on 2026-05-14.