FGF16

Overview

FGF16 encodes fibroblast growth factor 16, a ligand for FGF receptors involved in cell proliferation and survival signaling. In adenoid cystic carcinoma (ACC), FGF16 mutations are identified as part of a broader pattern of FGF/FGFR pathway alterations.

Alterations observed in the corpus

  • Mutation identified in adenoid cystic carcinoma (ACC) as part of FGF ligand alterations in the FGF/FGFR signaling axis PMID:23685749

Cancer types (linked)

  • ACC (adenoid cystic carcinoma) — mutation observed; FGF ligand alterations co-occur with receptor-level mutations (FGFR2, FGFR4) and downstream regulators (IL17RD, IGFBP2) in this tumor type PMID:23685749

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • FGF/FGFR pathway alterations in ACC nominate FGFR inhibitors as therapeutic candidates; activating FGFR2 mutations are the most actionable alteration in this pathway PMID:23685749

Open questions

  • Mutation frequency and functional consequence of FGF16 alterations in ACC not individually detailed PMID:23685749

Sources

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