FMN2
Overview
FMN2 (Formin 2) is an actin-nucleation factor involved in cytoskeletal organization. It was identified as having clustered/damaging mutations in small cell lung cancer (SCLC), though its functional role in cancer is not yet established.
Alterations observed in the corpus
- Clustered/damaging mutations in SCLC (110-tumour WGS cohort); also mutated in murine SCLC model (along with PTGFRN) PMID:26168399
Cancer types (linked)
- SCLC: Recurrently mutated in a 110-tumour WGS cohort PMID:26168399
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
Sources
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