FOXP3

Overview

FOXP3 is the master transcription factor of regulatory T cells (Tregs), and is used as a marker of immunoregulatory/counter-activation activity in tumor immune signatures.

Alterations observed in the corpus

  • Component of the 20-gene Immunologic Constant of Rejection (ICR) signature as an immunoregulatory counter-activation marker in colon cancer PMID:37202560.
  • FOXP3+ T regulatory cell surge in peripheral blood trended toward worse PFS (HR 1.42, P = .43) in the IMRT reirradiation + nivolumab trial for recurrent/second primary HNSCC (n=51) PMID:38780927.
  • FOXP3 was used as a CD4+/CD8+/FOXP3+ immune-cell phenotype marker to define infiltrating populations in a 44-specimen CyCIF/GeoMx spatial atlas of HGSOC fallopian tube precursors; FOXP3+ regulatory T cells detected as part of the immune infiltrate across progressive precursor stages PMID:39386723.
  • FOXP3 is a transcription factor stabilizing regulatory T cell (Treg) suppressive function in NPC; targeted indirectly by IKZF2 degraders (PLX-4545, DKY709) to reprogram Tregs and restore anti-tumor immunity. PMID:24952746
  • Used as an IHC marker for Treg quantification (clone 236A/E7) in the nivolumab-treated melanoma cohort; contributed to immune-cell-population analyses of the tumor microenvironment PMID:29033130

Cancer types (linked)

  • COAD — expression measured as part of the ICR signature in the AC-ICAM cohort, where ICR-high tumors carried better OS PMID:37202560.
  • HNSC — FOXP3+ T-cell surge post nivolumab + IMRT reirradiation trended toward worse PFS; hypothesis-generating peripheral blood biomarker (HR 1.42, P = .43) PMID:38780927.
  • HGSOC — FOXP3 used as a marker of infiltrating Treg populations in spatial immune profiling of fallopian tube precursor lesions PMID:39386723.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • Not reported as a direct target in the corpus; relevant as an ICR component for prognostic stratification PMID:37202560.

Open questions

  • None flagged in the corpus.

Sources

This page was processed by entity-page-writer on 2026-05-11. - PMID:24952746

This page was processed by entity-page-writer on 2026-05-11. - PMID:29033130

This page was processed by wiki-cli on 2026-05-15.