IDO1
Overview
IDO1 encodes indoleamine 2,3-dioxygenase 1, a tryptophan-catabolizing enzyme involved in immunoregulatory counter-activation in the tumor microenvironment.
Alterations observed in the corpus
- Immunoregulatory counter-activation component of the 20-gene ICR signature in colon cancer PMID:37202560.
- Marker of the immune-related ILC mRNA subtype identified in a comprehensive molecular portrait of invasive lobular breast cancer (n=127 ILC TCGA + n=106 LumA ILC) PMID:26451490
Cancer types (linked)
- COAD — ICR component in the AC-ICAM cohort PMID:37202560.
Co-occurrence and mutual exclusivity
- Co-expressed with CD274, CTLA4, FOXP3, PDCD1 in the ICR immunoregulatory arm PMID:37202560.
Therapeutic relevance
- Contributes to the ICR module; ICR-high tumors had better OS, and the paper notes potential predictive utility for immunotherapy response in other tumor types PMID:37202560.
Open questions
- None flagged in the corpus.
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:26451490
This page was processed by crosslinker on 2026-05-14.