FUBP1

Overview

FUBP1 (far upstream element binding protein 1) regulates MYC transcription and is recurrently mutated across several hematologic and CNS malignancies.

Alterations observed in the corpus

  • 20p loss and FUBP1 were identified as potentially initiating events in U-CLL by PhylogicNDT temporal ordering PMID:35927489.
  • FUBP1 mutations observed in 24% of 1p19q codeleted oligodendrogliomas in the MSK-IMPACT subcohort (n=73) of an IDH-mutant low-grade glioma active-surveillance study PMID:37910594.
  • Recurrent mutations in CLL (n=9, 1.7%); novel CLL driver with roles in RNA processing and MYC modulation PMID:26466571
  • Recurrently mutated in diffuse glioma (n=45 mutations recovered); confirmed known glioma driver along with TP53, EGFR, PTEN, CIC in pan-glioma TCGA methylation/genomic analysis (n=1122) PMID:26824661
  • Mutated in 5/19 (26%) FISH-confirmed 1p/19q-codeleted oligodendroglioma cases; canonical oligodendroglioma driver gene on chromosome 1p PMID:28472509

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • Not reported in the corpus.

Therapeutic relevance

  • Not reported in the corpus.

Open questions

  • Functional validation of FUBP1 as an early U-CLL driver is outstanding PMID:35927489.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:26466571

This page was processed by crosslinker on 2026-05-14. - PMID:26824661

This page was processed by wiki-cli on 2026-05-14. - PMID:28472509

This page was processed by wiki-cli on 2026-05-15.