PhylogicNDT

Overview

Phylogenetic and clonal-dynamics inference toolkit for reconstructing tumor evolution and the relative temporal order of somatic events from bulk sequencing.

Used by

• PMID:35927489 — used in the CLL-map cohort for temporal ordering of driver events: trisomy 12 was placed early; TP53/NOTCH1 intermediate in both IGHV subtypes; BRAF early in M-CLL but late in U-CLL (q<0.1); MYD88 early in M-CLL; 20p loss and FUBP1 potentially initiating in U-CLL PMID:35927489.

Notes

• Applied to CLL WES/WGS to derive subtype-specific evolutionary trajectories distinguishing M-CLL from U-CLL PMID:35927489.

Sources

• PMID:35927489

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