GATA4

Overview

GATA4 is a zinc-finger transcription factor of the GATA family with roles in cardiac and gastrointestinal development. In cancer, GATA4 is recurrently amplified in chromosomally unstable (CIN) gastric adenocarcinoma and in other gastrointestinal malignancies, where it may act as a lineage-specific oncogene.

Alterations observed in the corpus

• Focal amplification in CIN gastric adenocarcinoma (STAD) tumours (TCGA cohort) PMID:25079317
• Amplified in esophageal adenocarcinoma (EAC) in the TCGA multi-platform characterization; co-amplified with VEGFA and GATA6 as EAC-enriched events PMID:28052061.

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25079317

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