HMCN1
Overview
HMCN1 (Hemicentin-1) encodes a large extracellular matrix protein involved in cell-cell adhesion and tissue integrity. Frequent alterations in anaplastic thyroid carcinoma implicate HMCN1 in tumor cell migration and invasion.
Alterations observed in the corpus
- HMCN1 is a cell-adhesion gene with frequent alterations in anaplastic thyroid carcinoma (ATC) in the GATCI study (n=141 WES/WGS); implicated in tumor cell migration and invasion alongside HSPG2 PMID:38412093.
Cancer types (linked)
- THAP — recurrent alterations observed in ATC in the multi-site GATCI consortium (329 thyroid cancer regions across 292 patients, 15 institutions) PMID:38412093.
Co-occurrence and mutual exclusivity
- Co-altered with HSPG2 in ATC as part of a cell-adhesion gene alteration cluster PMID:38412093.
Therapeutic relevance
- No direct therapeutic targeting reported; cell-adhesion alterations may contribute to metastatic potential in ATC PMID:38412093.
Open questions
- Functional studies are needed to determine which specific HMCN1 mutations drive dedifferentiation or invasion in ATC PMID:38412093.
Sources
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