HSPG2
Overview
HSPG2 (Perlecan) encodes a heparan sulfate proteoglycan component of the extracellular matrix. Frequent alterations in anaplastic thyroid carcinoma implicate it in tumor cell migration and invasion alongside HMCN1.
Alterations observed in the corpus
- HSPG2 is a cell-adhesion gene with frequent alterations in anaplastic thyroid carcinoma (ATC) in the GATCI study (n=141 WES/WGS); implicated in tumor cell migration and invasion alongside HMCN1 PMID:38412093.
- Recurrent mutation in 7% of adenoid cystic carcinoma (ACC) samples; HSPG2 encodes perlecan, a basement-membrane proteoglycan that modulates FGF signaling PMID:23685749
Cancer types (linked)
- THAP — recurrent alterations observed in ATC in the multi-site GATCI consortium (329 thyroid cancer regions across 292 patients, 15 institutions) PMID:38412093.
Co-occurrence and mutual exclusivity
- Co-altered with HMCN1 in ATC as part of a cell-adhesion gene alteration cluster PMID:38412093.
Therapeutic relevance
- No direct therapeutic targeting reported; cell-adhesion alterations may contribute to metastatic potential in ATC PMID:38412093.
Open questions
- Functional studies are needed to determine which specific HSPG2 mutations contribute to ATC invasion PMID:38412093.
Sources
This page was processed by crosslinker on 2026-04-11. - PMID:23685749
This page was processed by wiki-cli on 2026-05-09.