HNF1A
Overview
HNF1A (Hepatocyte Nuclear Factor 1 Alpha) is a transcription factor critical for hepatocyte differentiation and liver-specific gene expression. In liver neoplasia, HNF1A mutations are primarily associated with hepatocellular adenomas (HCA) rather than classic hepatocellular carcinoma (HCC), supporting the conclusion that most HCC arising in non-fibrotic liver does not originate from HCA transformation.
Alterations observed in the corpus
- HNF1A mutated mostly in hepatocellular adenomas (HCA), not classic HCC; distribution supports the conclusion that most HCC arising in non-fibrotic liver does not originate from HCA transformation (243-case European WES cohort). PMID:25822088
Cancer types (linked)
- HCC: HNF1A mutations found predominantly in hepatocellular adenomas within the non-fibrotic liver subset rather than in classic HCC; used as molecular evidence against HCA-to-HCC transformation as a major pathway. PMID:25822088
Co-occurrence and mutual exclusivity
- HNF1A and IL6ST mutation distributions were jointly used to support the conclusion that non-fibrotic-liver HCC does not commonly arise via hepatocellular adenoma transformation. PMID:25822088
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus. PMID:25822088
Open questions
- The HCA-to-HCC transformation hypothesis based on HNF1A/IL6ST distribution would benefit from orthogonal molecular timing data. PMID:25822088
Sources
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