ITGAE
Overview
ITGAE (Integrin Subunit Alpha E) encodes integrin αE (CD103), a cell-adhesion protein involved in epithelial homing of immune cells. In pancreatic ductal adenocarcinoma (PAAD), ITGAE was identified as a MutSigCV-significant gene, though its role as a driver vs. passenger mutation remains to be functionally validated.
Alterations observed in the corpus
- Identified as a MutSigCV-significant gene in pancreatic ductal adenocarcinoma (PAAD) in a 109-case WES cohort; functional role in PDA biology not established — listed alongside other novel hits (IRF6, HDAC2, FLG, ATXN1, COL14A1, etc.) whose oncogenic vs. passenger status awaits orthogonal validation. PMID:25855536
Cancer types (linked)
- PAAD: MutSigCV-significant alteration in a 109-case whole-exome sequencing cohort; not previously highlighted as a PDA driver. PMID:25855536
Co-occurrence and mutual exclusivity
- Co-identified with other novel MutSigCV-significant genes in PDA; specific co-occurrence patterns with canonical drivers not reported. PMID:25855536
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus. PMID:25855536
Open questions
- Whether ITGAE mutations in PDA reflect an oncogenic role or are passengers requires functional validation. PMID:25855536
Sources
This page was processed by crosslinker on 2026-05-14.