KLF4
Overview
KLF4 (Kruppel-Like Factor 4) is a transcription factor involved in cell differentiation and pluripotency. In meningioma, KLF4 point mutations define a specific NF2-wildtype molecular subgroup (MG2) with typically benign clinical behavior.
Alterations observed in the corpus
- KLF4 point mutations are found exclusively in the MG2 meningioma molecular group (13% frequency), an NF2-wildtype subtype that also harbors TRAF7 (25%), AKT1 (13%), and SMO mutations in a clinically integrative molecular classification of 201 meningiomas PMID:34433969.
- Regulon activity retained in the LASSO Cox multivariate survival model for MIBC (n=412), associated with worse survival. PMID:28988769
Cancer types (linked)
- MNG — KLF4 mutations define the NF2-wildtype MG2 molecular group, which is associated with typically benign histology and potential amenability to targeted therapies against TRAF7/AKT1/KLF4/SMO pathways PMID:34433969.
Co-occurrence and mutual exclusivity
- Co-occurs with TRAF7 mutations in MG2 meningiomas; both are exclusive to NF2-wildtype tumors and mutually exclusive with NF2 mutations PMID:34433969.
Therapeutic relevance
- MG2 meningiomas harboring TRAF7/AKT1/KLF4/SMO mutations may be amenable to targeted therapies directed at these specific pathways, including AKT and SMO inhibitors PMID:34433969.
Open questions
- The mechanistic basis of KLF4 mutations in meningioma oncogenesis and whether they confer sensitivity to specific targeted agents requires functional validation PMID:34433969.
Sources
This page was processed by crosslinker on 2026-05-04. - PMID:28988769
This page was processed by entity-page-writer on 2026-05-15.