KLHL14
Overview
KLHL14 (Kelch-Like Family Member 14) encodes a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex. In cancer genomics, KLHL14 alterations have been associated with poorer overall survival in the ABC subtype of diffuse large B-cell lymphoma (DLBCL).
Alterations observed in the corpus
- Alterations associated with poorer overall survival in ABC DLBCL in a 1001-patient cohort treated with rituximab-containing regimens. PMID:28985567
Cancer types (linked)
- DLBCL NOS: KLHL14 alterations carry adverse prognostic significance specifically in the ABC cell-of-origin subtype within the 150-driver-gene landscape analysis. PMID:28985567
Co-occurrence and mutual exclusivity
- Grouped with BTG1 and PAX5 as genes whose alterations are associated with poorer survival in ABC DLBCL. PMID:28985567
Therapeutic relevance
- No direct targeted therapy against KLHL14 is reported in this corpus. Its adverse prognostic role in ABC DLBCL may help identify high-risk patients for more intensive or novel therapeutic approaches. PMID:28985567
Open questions
- The specific alteration types (mutation, copy-number loss, other) driving KLHL14’s adverse prognostic impact in ABC DLBCL are not detailed separately in this study. PMID:28985567
Sources
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