MACF1
Overview
MACF1 (Microtubule Actin Crosslinking Factor 1) is a spectraplakin that links the actin and microtubule cytoskeletons. In cancer, MACF1 functions as a WNT/β-catenin pathway inhibitor by facilitating AXIN complex–mediated β-catenin degradation. It was newly identified as a recurrently mutated WNT-pathway regulator in hepatocellular carcinoma (HCC).
Alterations observed in the corpus
- MACF1 newly highlighted as a recurrently mutated β-catenin–pathway inhibitor in HCC (243-case European WES cohort); identified alongside ZNRF3 and USP34 as novel WNT-pathway regulators in HCC. PMID:25822088
Cancer types (linked)
- HCC: Recurrently mutated in a 243-case European WES cohort; grouped with other β-catenin pathway inhibitors (ZNRF3, USP34) newly highlighted in HCC. PMID:25822088
Co-occurrence and mutual exclusivity
- Co-identified with other WNT-pathway regulators ZNRF3 and USP34 as recurrently mutated β-catenin inhibitors in HCC. PMID:25822088
Therapeutic relevance
- As a WNT-pathway component, MACF1 loss may contribute to β-catenin pathway activation; no specific therapy reported in the corpus. PMID:25822088
Open questions
- Functional validation of MACF1 as a tumour suppressor in the WNT pathway in HCC is needed. PMID:25822088
Sources
This page was processed by crosslinker on 2026-05-14.