USP34

Overview

USP34 (Ubiquitin Specific Peptidase 34) is a deubiquitinase involved in WNT/β-catenin pathway regulation through its role in stabilising AXIN. In hepatocellular carcinoma, USP34 was newly highlighted as a recurrently mutated β-catenin pathway inhibitor.

Alterations observed in the corpus

• Newly highlighted as a recurrently mutated β-catenin pathway inhibitor in hepatocellular carcinoma (alongside ZNRF3 and MACF1); part of the WNT/β-catenin pathway (54% altered) in HCC. PMID:25822088

Cancer types (linked)

• HCC: Recurrently mutated β-catenin pathway member; specific frequency not reported separately. Part of the WNT pathway (CTNNB1 central node, 54% pathway alteration). PMID:25822088

Co-occurrence and mutual exclusivity

• Co-occurs with other WNT pathway members (CTNNB1, AXIN1, ZNRF3, MACF1) in HCC. PMID:25822088

Therapeutic relevance

• WNT/β-catenin pathway inhibitors may be relevant in USP34-mutant HCC; no direct therapeutic evidence reported in the corpus.

Open questions

• Individual mutation frequency and functional consequences of USP34 loss in HCC β-catenin regulation require further characterisation.

Sources

• PMID:25822088

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