MACROD2

Overview

MACROD2 (Mono-ADP-Ribosylhydrolase 2) encodes a hydrolase that removes ADP-ribose modifications from proteins. In cancer genomics, MACROD2 has attracted attention primarily as a recurrently rearranged locus in melanoma whole-genome sequencing studies. Its precise oncogenic role remains under investigation.

Alterations observed in the corpus

• MACROD2 is recurrently rearranged in 5/25 metastatic melanomas by whole-genome sequencing; among the most frequently rearranged loci in the discovery cohort PMID:22622578

Cancer types (linked)

• SKCM (Melanoma): Structural rearrangements affecting MACROD2 detected in 5/25 WGS discovery tumors PMID:22622578

Co-occurrence and mutual exclusivity

• Co-occurs with other recurrently rearranged loci (PTEN, MAGI2, FHIT, CSMD1, RBFOX1) in melanoma PMID:22622578

Therapeutic relevance

• No targeted therapies against MACROD2 are currently described in the corpus.

Open questions

• Functional consequences of MACROD2 rearrangements in melanoma remain uncharacterized.

Sources

• PMID:22622578

This page was processed by entity-page-writer on 2026-05-06.