MAP3K5
Overview
MAP3K5 (also known as ASK1, Apoptosis Signal-regulating Kinase 1) encodes a serine/threonine kinase that activates the JNK and p38 MAPK pathways, playing a central role in regulating apoptosis in response to oxidative stress and inflammatory signals. In cancer genomics, MAP3K5 has been identified as a recurrent fusion partner with NFIB in adenoid cystic carcinoma (ACC), suggesting a role in the oncogenic rearrangement landscape of this tumor type.
Alterations observed in the corpus
- Recurrent NFIB fusion partner in adenoid cystic carcinoma (ACC): MAP3K5–NFIB fusions detected in 2/25 tumors; MAP3K5 encodes a serine/threonine kinase regulating apoptosis PMID:26862087
Cancer types (linked)
- ACC (adenoid cystic carcinoma): recurrent MAP3K5–NFIB fusion partner (2/25 tumors) PMID:26862087
Co-occurrence and mutual exclusivity
Therapeutic relevance
- No direct therapeutic targeting reported in this corpus.
Open questions
- Functional consequences of the MAP3K5–NFIB fusion on apoptosis signaling and oncogenesis in ACC remain to be characterized.
Sources
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