MYO6

Overview

MYO6 encodes an unconventional myosin motor protein that moves toward the minus (pointed) end of actin filaments — unique among myosins. It participates in endocytosis, vesicle trafficking, and Golgi complex organization. In cancer, MYO6 has been identified as a rare recurrent fusion partner with NFIB on chromosome 6q in adenoid cystic carcinoma (ACC).

Alterations observed in the corpus

• Single-tumor NFIB fusion partner on chromosome 6q in ACC PMID:26862087

Cancer types (linked)

• ACC (adenoid cystic carcinoma): single-tumor MYO6–NFIB intrachromosomal fusion (chromosome 6q) PMID:26862087

Co-occurrence and mutual exclusivity

• MYO6–NFIB fusion occurs alongside other NFIB rearrangements (MYB, MAP3K5, MYBL1, RIMS1, RPS6KA2) in ACC cohort PMID:26862087

Therapeutic relevance

• No direct therapeutic targeting reported in this corpus.

Open questions

• The functional consequence of MYO6–NFIB fusion on tumor biology is unknown.

Sources

• PMID:26862087

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