MEOX2
Overview
MEOX2 (Mesenchyme Homeobox 2) is a paired-like homeobox transcription factor involved in mesenchymal cell differentiation, vascular smooth muscle cell quiescence, and skeletal muscle development. It has been studied in the context of vascular biology and tumor suppression. In extra-cranial MRT, MEOX2 is among the most over-expressed genes in mRNA sub-group 1, which is characterized by BMP signaling and differentiation pathway activity.
Alterations observed in the corpus
- MEOX2 is among the most over-expressed genes in mRNA sub-group 1 of extra-cranial MRT (a BMP signaling / differentiation sub-group), alongside BMP4 and DLK1; this sub-group parallels features of the AT/RT SHH/MYC subtype PMID:26977886
Cancer types (linked)
- MRT (Malignant Rhabdoid Tumor): MEOX2 over-expression is a defining feature of mRNA sub-group 1 in the 40-sample extra-cranial MRT WGS/RNA-seq cohort. PMID:26977886
Co-occurrence and mutual exclusivity
- MEOX2 over-expression co-occurs with BMP4 and DLK1 over-expression in mRNA sub-group 1 MRT, distinct from MEIS1/WNT5A/PCDH18 over-expression in sub-group 2. PMID:26977886
Therapeutic relevance
- No therapeutic implications described in the corpus; MEOX2 over-expression is a molecular sub-group marker in MRT.
Open questions
- Whether MEOX2 over-expression reflects a specific cell-of-origin for MRT sub-group 1 or is a consequence of SMARCB1 loss and epigenomic reprogramming is not determined. PMID:26977886
Sources
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