MIR21

Overview

MIR21 (MicroRNA 21) is one of the most widely overexpressed microRNAs in human cancer. It targets multiple tumor suppressor genes including PTEN, PDCD4, and SPRY2, promoting cell survival, proliferation, and invasion. In lung cancer, MIR21 is located within a novel focal amplification region identified by TCGA pan-lung analysis.

Alterations observed in the corpus

• MIR21 resides within a novel focal amplification region (together with TUBD1) in lung adenocarcinoma identified in pan-lung cancer TCGA analysis (n=1144) PMID:27158780

Cancer types (linked)

• Lung adenocarcinoma: focal amplification of MIR21/TUBD1 locus PMID:27158780

Co-occurrence and mutual exclusivity

• Focal amplification co-occurs with TUBD1 at the same genomic locus in lung ADC PMID:27158780

Therapeutic relevance

• MIR21 amplification in lung ADC may represent an oncogenic driver with potential as a therapeutic target; specific therapeutic strategies not yet established in this cohort PMID:27158780

Open questions

• Whether MIR21 or TUBD1 is the primary target of the focal amplification at this locus in lung ADC has not been resolved PMID:27158780

Sources

• PMID:27158780

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