TUBD1
Overview
TUBD1 (Tubulin Delta 1) encodes a delta-tubulin component involved in centriole structure and function. It resides in the chromosomal region amplified along with MIR21 in lung adenocarcinoma. TUBD1 itself has not been established as a direct cancer driver; its co-amplification with the oncogenic microRNA MIR21 makes it a passenger candidate in this focal amplification peak.
Alterations observed in the corpus
- Co-amplified with MIR21 in a novel focal amplification peak identified in lung ADC (LUAD) in a 1,144-NSCLC exome-sequencing cohort (660 ADC, 484 SqCC); the MIR21/TUBD1 locus was one of several novel amplification targets identified PMID:27158780.
Cancer types (linked)
- LUAD: Co-amplified with MIR21 in a novel focal amplification peak in lung adenocarcinoma PMID:27158780.
Co-occurrence and mutual exclusivity
- Co-localized with MIR21 in the same focal amplification peak; the oncogenic driver in this region is presumed to be MIR21, with TUBD1 as a potential passenger PMID:27158780.
Therapeutic relevance
- No direct therapeutic relevance for TUBD1 mutations or amplifications was discussed in the citing study PMID:27158780.
Open questions
- Whether TUBD1 amplification contributes independently to tumor biology beyond co-amplification with MIR21 has not been determined PMID:27158780.
Sources
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