MRPS31
Overview
MRPS31 (Mitochondrial Ribosomal Protein S31) is a component of the mitochondrial small ribosomal subunit. In cutaneous melanoma, MRPS31 was identified as a significantly mutated gene (SMG) with UV-induced 5′ UTR hot-spots, a novel class of mutations affecting ribosomal protein genes. Its function as a melanoma driver remains to be validated.
Alterations observed in the corpus
- MRPS31 identified as a ribosomal-protein SMG with UV-induced 5′ UTR hot-spots (~5% frequency) in cutaneous melanoma (TCGA 333-sample multi-platform cohort); nominated alongside RPS27 (~9%) as a novel class of melanoma SMGs with 5′ UTR mutations affecting translation. PMID:26091043
- Functional characterisation as a melanoma driver is pending; listed among genes where novel SMG status is not yet functionally validated. PMID:26091043
Cancer types (linked)
- SKCM: Significantly mutated at ~5% frequency with UV-signature 5′ UTR hot-spots; part of a novel ribosomal-protein SMG class in the TCGA cutaneous melanoma dataset. PMID:26091043
Co-occurrence and mutual exclusivity
- Co-identified with RPS27 as a ribosomal-protein SMG; RPS27 5′ TOP element regulates translation downstream of PI3K/AKT/mTOR. PMID:26091043
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus. PMID:26091043
Open questions
- Whether MRPS31 5′ UTR mutations alter translational regulation and contribute oncogenic function in melanoma requires functional validation. PMID:26091043
Sources
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