NCOR2

Overview

NCOR2 (Nuclear Receptor Corepressor 2, also known as SMRT) encodes a transcriptional corepressor that interacts with nuclear receptors and represses transcription. Recurrent alterations in NCOR2 have been identified in fusion-positive rhabdomyosarcoma (FP-RMS).

Alterations observed in the corpus

  • Recurrent alterations in fusion-positive rhabdomyosarcoma (FP-RMS) identified in a sequential multi-platform genomic study of 35 tumor pairs from 27 patients PMID:37730754.
  • Recurrently deleted in prostate cancer identified in integrative genomic profiling of 218 tumors PMID:20579941
  • Nonsense mutation identified in SHH-subgroup medulloblastoma in WES of 92 tumors (Broad cohort); component of the nuclear co-repressor complex PMID:22820256
  • In mCRPC, NCOR2 was identified as an AR pathway regulator recurrently altered in the 150-patient SU2C–PCF prospective cohort. PMID:26000489
  • AR co-activator alteration enriched in CRPC-Adeno (21 cases) vs. CRPC-NE PMID:26855148
  • NCOR2 is one of only two genes (alongside CSMD1) from 51 metastasis-private non-synonymous variants in patient 99-091 that are altered at >5% frequency in TCGA PRAD or SU2C mCRPC datasets, suggesting most private mutations at metastatic sites are passenger events PMID:26928463

Cancer types (linked)

  • Fusion-positive rhabdomyosarcoma (FP-RMS) — recurrent secondary alterations alongside IGF2 and MED12 PMID:37730754.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic link reported in the corpus.

Open questions

  • The functional significance of NCOR2 alterations in FP-RMS progression and their relationship to the PAX::FOXO1 fusion-driven transcriptional program is not characterized.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:20579941

This page was processed by crosslinker on 2026-05-14. - PMID:22820256

This page was processed by crosslinker on 2026-05-14. - PMID:26000489

This page was processed by crosslinker on 2026-05-14. - PMID:26855148

This page was processed by wiki-cli on 2026-05-14. - PMID:26928463

This page was processed by wiki-cli on 2026-05-14.