NKAIN2

Overview

NKAIN2 (Na+/K+ Transporting ATPase Interacting 2) encodes a membrane protein involved in ion transport regulation. In adenoid cystic carcinoma, NKAIN2 has been identified as a novel 5’-NFIB fusion partner in a subset of tumors.

Alterations observed in the corpus

• Novel 5’-NFIB fusion partner in adenoid cystic carcinoma (ACC); identified alongside XRCC4, PTPRD, and AIG1 as alternative NFIB partners in t(6;9)-positive/MYB-NFIB-negative tumors PMID:26631609

Cancer types (linked)

• Adenoid cystic carcinoma: 5’-NFIB fusion partner in a subset of t(6;9)-positive tumors lacking canonical MYB-NFIB fusion PMID:26631609

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26631609

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