PTPRD

Overview

PTPRD (protein tyrosine phosphatase receptor type D) encodes a receptor-type phosphatase that functions as a tumor suppressor. PTPRD inactivation through mutations and deletions has been observed in multiple cancer types, including radiation-associated sarcomas.

Alterations observed in the corpus

  • Mutations and deletions in 25% of RT-MPNST vs 5% of sporadic MPNST, indicating significant enrichment in radiation-associated malignant peripheral nerve sheath tumors PMID:37350195.
  • Frequently mutated and previously shown deleted in LUAD; co-mutates with PIK3C3 in the TSP cohort (n=188). PMID:18948947
  • 27 mutations in 17 tumors across protein tyrosine phosphatase receptor domains in the 147-tumor Yale melanoma WES cohort PMID:22842228
  • Highlighted in focal-deletion and TieDIE pathway analyses in ccRCC (TCGA 450-case cohort) as a downstream pathway and SCNA feature PMID:23792563
  • Recurrent homozygous deletion in multiple myeloma; proposed to feed into IL6/STAT3 signaling as a tumor suppressor through STAT3 dephosphorylation PMID:24434212
  • Novel 5’-NFIB fusion partner in adenoid cystic carcinoma; identified in t(6;9)-positive/MYB-NFIB-negative tumors PMID:26631609
  • PTPRD tumor-suppressor alterations flagged as actionable in a targeted sequencing study of germ cell tumors, particularly among cisplatin-resistant patients PMID:27646943.
  • PTPRD less frequently mutated in the MSK metastatic gastroesophageal cohort vs TCGA non-MSI-H (q<=0.10), suggesting selective pressure against PTPRD mutations in metastatic disease PMID:29122777

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • Not specifically reported in the corpus for PTPRD partners PMID:37350195.

Therapeutic relevance

  • No PTPRD-directed therapy is reported in this corpus PMID:37350195.

Open questions

  • The functional consequences of PTPRD loss in MPNST pathogenesis and whether it cooperates with other enriched RT-MPNST alterations (e.g., NF1, CDKN2A) remain to be determined PMID:37350195.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:18948947

This page was processed by crosslinker on 2026-05-09. - PMID:22842228

This page was processed by crosslinker on 2026-05-09. - PMID:23792563

This page was processed by crosslinker on 2026-05-09. - PMID:24434212

This page was processed by crosslinker on 2026-05-09. - PMID:26631609

This page was processed by entity-page-writer on 2026-05-15. - PMID:27646943

This page was processed by entity-page-writer on 2026-05-15. - PMID:29122777

This page was processed by wiki-cli on 2026-05-15.