NKX3-1

Overview

NKX3-1 is a homeobox transcription factor. In the corpus it appears as a gene whose alterations associate with local intracranial progression of NSCLC brain metastases.

Alterations observed in the corpus

  • Alterations enriched in local intracranial progressors after craniotomy + RT for LUAD brain metastases (16% vs 3% in non-progressors; p=0.044) PMID:37591896.
  • Recurrent post-treatment alteration and association with Gleason/metastasis in PRAD in the MSK-CHORD pan-cancer real-world cohort (n=52,211); NKX3-1 listed alongside AR, CDK12, and FOXA1 as recurrent post-treatment PRAD alterations. PMID:39506116
  • Recurrently deleted in prostate cancer identified in integrative genomic profiling of 218 tumors PMID:20579941
  • NKX3-1 somatic mutations detected in prostate cancer; identified in WES of 112 primary tumors (Broad Institute cohort) PMID:22610119
  • Strictly clonal deletion in 8 of 26 prostate tumors via chromoplexy; identified as one of the earliest detectable lesions in prostate carcinogenesis based on clonality analysis (p=10⁻⁵ for NKX3-1 deletion being earlier than PTEN) PMID:23622249
  • Significantly mutated in prostate adenocarcinoma (somatic mutation in ~1%); also commonly deleted; listed among significantly mutated genes in the TCGA cohort (n=333) PMID:26544944

Cancer types (linked)

  • Lung adenocarcinoma (LUAD) — associated with local intracranial progression PMID:37591896.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic link reported in the corpus.

Open questions

  • Mechanism linking NKX3-1 alteration to local CNS recurrence is untested.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:20579941

This page was processed by crosslinker on 2026-05-09. - PMID:22610119

This page was processed by crosslinker on 2026-05-09. - PMID:23622249

This page was processed by crosslinker on 2026-05-09. - PMID:26544944

This page was processed by wiki-cli on 2026-05-14.