OMG
Overview
OMG (oligodendrocyte myelin glycoprotein) is a glycosylphosphatidylinositol-anchored protein expressed in myelinating oligodendrocytes and Schwann cells. In oligodendroglioma, OMG marks the differentiated oligodendrocyte-like tumor cell subpopulation and is used as a lineage marker in single-cell transcriptomic analyses.
Alterations observed in the corpus
- OMG is highly expressed in differentiated oligodendrocyte-like tumor cells in grade II oligodendroglioma (IDH-mutant, 1p/19q codeleted), alongside OLIG1 and OLIG2; RNA in situ hybridization for OMG was used as one of the orthogonal validation assays for the scRNA-seq oligodendrocytic lineage assignments PMID:27806376.
Cancer types (linked)
- ODG — OMG marks differentiated oligodendrocyte-like cells; used with OLIG1/OLIG2 to define the oligodendrocytic compartment in the scRNA-seq developmental hierarchy PMID:27806376.
Co-occurrence and mutual exclusivity
- Co-expressed with OLIG1, OLIG2 in oligodendrocyte-like cells; mutually exclusive with astrocyte-like (GFAP, APOE) program at single-cell resolution PMID:27806376.
Therapeutic relevance
- Not directly targeted; OMG expression identifies the non-proliferating differentiated fraction of oligodendroglioma that is distinct from the therapeutically relevant stem/progenitor subpopulation PMID:27806376.
Open questions
- The functional role of OMG in oligodendroglioma biology beyond serving as a lineage marker is not investigated PMID:27806376.
Sources
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