PHF3
Overview
PHF3 (PHD Finger Protein 3) is a chromatin-associated protein containing a plant homeodomain (PHD) zinc-finger motif. It functions in transcriptional regulation. In lung squamous cell carcinoma, PHF3 was identified as a novel focal amplification target.
Alterations observed in the corpus
- PHF3 identified as a novel focal amplification target gene in lung SqCC (co-amplified with PTP4A1 at the same focal peak) in the 1,144-tumor NSCLC landscape study (660 lung ADC, 484 lung SqCC; GISTIC2.0 analysis). PMID:27158780
Cancer types (linked)
- LUSC: PHF3 locus is a novel focal amplification peak specifically identified in lung squamous cell carcinoma; co-amplified with PTP4A1 at the same genomic peak. PMID:27158780
Co-occurrence and mutual exclusivity
- Co-amplified with PTP4A1 at the same focal GISTIC2.0 peak in lung SqCC. PMID:27158780
Therapeutic relevance
- No direct therapeutic relevance reported in the current corpus.
Open questions
- Whether PHF3 or PTP4A1 is the functional driver of the focal amplification peak in lung SqCC has not been resolved.
Sources
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